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operant conditioning chambers  (Coulbourn Instruments)

 
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    Coulbourn Instruments operant conditioning chambers
    Operant Conditioning Chambers, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/operant+conditioning+chambers/chambers+operant/pmc08550898-37-9-17
    Average 86 stars, based on 1 article reviews
    operant conditioning chambers - by Bioz Stars, 2026-09
    86/100 stars

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    Related Articles

    Isolation:

    Article Title: Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats
    Article Snippet: Fear conditioning, extinction, long-term memory test, and reinstatement were all administered in the same context (operant conditioning chambers; Coulbourn Instruments, Whitehall, PA).

    Article Title: Associations of CO 2 reactivity and orexin activity with extinction memory to fear and reward cues: results from a large sample of male rats across multiple studies.
    Article Snippet: Pavlovian conditioning can be used to model maladaptive associations seen in anxiety/trauma and substance use disorders.. One approach to attenuate conditioned responses is extinction learning (which underlies exposure therapy), wherein cues are repeatedly presented without the expected fearful or rewarding outcome.. Extinction is not effective for all; therefore, identifying biomarkers that can phenotype non-responders is necessary to optimize treatment.

    Article Title: Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats.
    Article Snippet: The behavioral sessions (thirty-minute sessions, five days a week) were conducted in operant conditioning chambers (30.5cm x 25.4cm x 30.5cm; Coulbourn Instruments, USA) during the light period.

    Article Title: The role of IL-6 in dopamine dysregulation underlying anhedonia phenotype in rats
    Article Snippet: The behavioural sessions (30-minute sessions, five days a week) were conducted in operant conditioning chambers (30.5cm x 25.4cm x 30.5cm; Coulbourn Instruments, USA) during the light period.

    Article Title: Examining the long-term effects of traumatic brain injury on fear extinction in male rats
    Article Snippet: All experimental manipulations (fear conditioning, extinction, fear expression) were administered in the same context (operant conditioning chambers; Coulbourn Instruments, Whitehall, PA, USA).



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    a Schematic of the experiment. Grpr fl/fl or fl/y mice were injected bilaterally with AAV5-hSYN-GFP or AAV5-hSYN-Cre-GFP in the NAc MSh. b Sample image of the injection site in the NAc MSh showing AAV-Cre-GFP in green with nuclei labeled in blue with DAPI (representative of 14 mice). c Schematic of the progressive ratio (PR) lever pressing test and timeline for operant <t>conditioning.</t> RT = random timing, FR1 = fixed ratio 1. d Box plots of the number of days it took control (GFP-injected, green) and Grpr cKO (Cre-injected, black) mice to reach criterion (boxes represent the interquartile range (25 – 75%), lines denote the median, whiskers represent mix to max values) (two-tailed Mann-Whitney test, p = 0.4522; n = 22 GFP and n = 14 Cre mice). e Mea n ± SEM weight of GFP and Cre-injected mice just prior to starting food deprivation (two-tailed Mann-Whitney test, p = 0.8917, n is the same as panel ( d ). f Mean ± SEM percentage of starting weight per mouse on the day the mouse completed the PR task (two-tailed Mann-Whitney test, p = 0.4192). g Survival function of total session time on PR testing day. The session ended when a mouse went three minutes without pressing the lever after pressing the lever at least one time (Mantel-Cox test, **p = 0.0054). h Mea n ± SEM total lever presses in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0077). i Mean ± SEM breakpoint in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0060). j Mean ± SEM total session time during the PR task before timeout (two-tailed Mann-Whitney test, * p = 0.0381). k Raster plot of lever presses per individual mouse during the PR task. Each line represents a single lever press. Each row represents the lever-pressing data of an individual mouse. For all bar graphs, dots represent values for individual mice. For panels d-k, n = 22 GFP-injected (green, control) and n = 14 Cre-injected (black, Grpr cKO) mice. Source data are provided as a Source Data file.
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    a Schematic of the experiment. Grpr fl/fl or fl/y mice were injected bilaterally with AAV5-hSYN-GFP or AAV5-hSYN-Cre-GFP in the NAc MSh. b Sample image of the injection site in the NAc MSh showing AAV-Cre-GFP in green with nuclei labeled in blue with DAPI (representative of 14 mice). c Schematic of the progressive ratio (PR) lever pressing test and timeline for operant <t>conditioning.</t> RT = random timing, FR1 = fixed ratio 1. d Box plots of the number of days it took control (GFP-injected, green) and Grpr cKO (Cre-injected, black) mice to reach criterion (boxes represent the interquartile range (25 – 75%), lines denote the median, whiskers represent mix to max values) (two-tailed Mann-Whitney test, p = 0.4522; n = 22 GFP and n = 14 Cre mice). e Mea n ± SEM weight of GFP and Cre-injected mice just prior to starting food deprivation (two-tailed Mann-Whitney test, p = 0.8917, n is the same as panel ( d ). f Mean ± SEM percentage of starting weight per mouse on the day the mouse completed the PR task (two-tailed Mann-Whitney test, p = 0.4192). g Survival function of total session time on PR testing day. The session ended when a mouse went three minutes without pressing the lever after pressing the lever at least one time (Mantel-Cox test, **p = 0.0054). h Mea n ± SEM total lever presses in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0077). i Mean ± SEM breakpoint in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0060). j Mean ± SEM total session time during the PR task before timeout (two-tailed Mann-Whitney test, * p = 0.0381). k Raster plot of lever presses per individual mouse during the PR task. Each line represents a single lever press. Each row represents the lever-pressing data of an individual mouse. For all bar graphs, dots represent values for individual mice. For panels d-k, n = 22 GFP-injected (green, control) and n = 14 Cre-injected (black, Grpr cKO) mice. Source data are provided as a Source Data file.
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    Image Search Results


    a Schematic of the experiment. Grpr fl/fl or fl/y mice were injected bilaterally with AAV5-hSYN-GFP or AAV5-hSYN-Cre-GFP in the NAc MSh. b Sample image of the injection site in the NAc MSh showing AAV-Cre-GFP in green with nuclei labeled in blue with DAPI (representative of 14 mice). c Schematic of the progressive ratio (PR) lever pressing test and timeline for operant conditioning. RT = random timing, FR1 = fixed ratio 1. d Box plots of the number of days it took control (GFP-injected, green) and Grpr cKO (Cre-injected, black) mice to reach criterion (boxes represent the interquartile range (25 – 75%), lines denote the median, whiskers represent mix to max values) (two-tailed Mann-Whitney test, p = 0.4522; n = 22 GFP and n = 14 Cre mice). e Mea n ± SEM weight of GFP and Cre-injected mice just prior to starting food deprivation (two-tailed Mann-Whitney test, p = 0.8917, n is the same as panel ( d ). f Mean ± SEM percentage of starting weight per mouse on the day the mouse completed the PR task (two-tailed Mann-Whitney test, p = 0.4192). g Survival function of total session time on PR testing day. The session ended when a mouse went three minutes without pressing the lever after pressing the lever at least one time (Mantel-Cox test, **p = 0.0054). h Mea n ± SEM total lever presses in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0077). i Mean ± SEM breakpoint in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0060). j Mean ± SEM total session time during the PR task before timeout (two-tailed Mann-Whitney test, * p = 0.0381). k Raster plot of lever presses per individual mouse during the PR task. Each line represents a single lever press. Each row represents the lever-pressing data of an individual mouse. For all bar graphs, dots represent values for individual mice. For panels d-k, n = 22 GFP-injected (green, control) and n = 14 Cre-injected (black, Grpr cKO) mice. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation

    doi: 10.1038/s41467-025-64373-3

    Figure Lengend Snippet: a Schematic of the experiment. Grpr fl/fl or fl/y mice were injected bilaterally with AAV5-hSYN-GFP or AAV5-hSYN-Cre-GFP in the NAc MSh. b Sample image of the injection site in the NAc MSh showing AAV-Cre-GFP in green with nuclei labeled in blue with DAPI (representative of 14 mice). c Schematic of the progressive ratio (PR) lever pressing test and timeline for operant conditioning. RT = random timing, FR1 = fixed ratio 1. d Box plots of the number of days it took control (GFP-injected, green) and Grpr cKO (Cre-injected, black) mice to reach criterion (boxes represent the interquartile range (25 – 75%), lines denote the median, whiskers represent mix to max values) (two-tailed Mann-Whitney test, p = 0.4522; n = 22 GFP and n = 14 Cre mice). e Mea n ± SEM weight of GFP and Cre-injected mice just prior to starting food deprivation (two-tailed Mann-Whitney test, p = 0.8917, n is the same as panel ( d ). f Mean ± SEM percentage of starting weight per mouse on the day the mouse completed the PR task (two-tailed Mann-Whitney test, p = 0.4192). g Survival function of total session time on PR testing day. The session ended when a mouse went three minutes without pressing the lever after pressing the lever at least one time (Mantel-Cox test, **p = 0.0054). h Mea n ± SEM total lever presses in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0077). i Mean ± SEM breakpoint in the PR session before timeout (two-tailed Mann-Whitney test, ** p = 0.0060). j Mean ± SEM total session time during the PR task before timeout (two-tailed Mann-Whitney test, * p = 0.0381). k Raster plot of lever presses per individual mouse during the PR task. Each line represents a single lever press. Each row represents the lever-pressing data of an individual mouse. For all bar graphs, dots represent values for individual mice. For panels d-k, n = 22 GFP-injected (green, control) and n = 14 Cre-injected (black, Grpr cKO) mice. Source data are provided as a Source Data file.

    Article Snippet: Animals were food restricted to ∼90-95% of their body weight before commencing training in an operant conditioning chamber (Med Associates: ENV-307A).

    Techniques: Injection, Labeling, Control, Two Tailed Test, MANN-WHITNEY